Relationship between Apelin/APJ Signaling, Oxidative Stress, and Diseases

Apelin, a peptide hormone, is an endogenous ligand for G protein-coupled receptor and has been shown to be widely expressed in human animal tissues, such as the central nervous system adipose tissue. Recent studies indicate that apelin/APJ involved regulation of multiple physiological pathological processes, it associated with cardiovascular diseases, metabolic disorders, neurological ischemia-reperfusion injury, aging, eclampsia, deafness, tumors. The occurrence development these diseases are closely related local inflammatory response. Oxidative stress balance between oxidation antioxidant broken, reactive oxygen species produced large quantities, causing cell or molecular damage, which leads vascular damage series reactions. Hence, this article reviewed recent advances relationship oxidative stress, inflammation-related highlights them potential therapeutic targets stress-related diseases.